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Not to be confused with phenobarbital or sodium pentothal.
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Pharmacology
[edit]
Pharmacodynamics
[edit]
Like other barbiturates, pentobarbital binds to the barbiturate-binding site on the GABA-A receptor. This action increases the duration of ion-channel opening. At high doses, pentobarbital is capable of opening the ion channel in the absence of GABA.[25]
Pharmacokinetics
[edit]
Pentobarbital undergoes first-pass metabolism in the liver and possibly the intestines.[26]
Drug interactions
[edit]
The administration of ethanol, benzodiazepines, opioids, antihistamines, other sedative-hypnotics, and other central nervous system depressants will cause possible additive effects.[8]
Chemistry
[edit]
Pentobarbital is synthesized by methods analogous to that of amobarbital, the only difference being that the alkylation of α-ethylmalonic ester is carried out with 2-bromopentane in place of 1-bromo-3-methylbutane to give pentobarbital.[27][28][29]
Pentobarbital can occur as a free acid but is usually formulated as the sodium salt, pentobarbital sodium. The free acid is only slightly soluble in water and in ethanol[30][31] while the sodium salt shows better solubility.
Society and culture
[edit]
Pentobarbital is the INN, AAN, BAN, and USAN while pentobarbitone is a former AAN and BAN.
One brand name for this drug is Nembutal, coined by John S. Lundy, Buy Nembutal Powder Online who started using it in 1930, from the structural formula of the sodium salt—Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates).[32] Nembutal is trademarked and manufactured by the Danish pharmaceutical company Lundbeck (now produced by Akorn Pharmaceuticals) is the only injectable form of pentobarbital approved for sale in the United States.
